Kelly M. Blaine

Research Lab Manager

Kelly grew up in the western suburbs of Chicago and graduated with her Master of Science degree from Northern Illinois University. She began working at the University of Chicago in 1997, spending her first 5 years in Dr. Jim Miller's lab in MGCB. 

In her free time she enjoys hiking, gardening, photography, and caring for her two rescued rabbits, Stuart and Walt. 

She then worked 19 years for Dr. Anne Sperling in the Department of Medicine, studying asthma, airway inflammation, and idiopathic pulmonary fibrosis. She managed the processing of human tissues and the creation of a human cell bank for the lab, and conducted fluorescence microscopy experiments for graduate student projects. 

Current Research

tbd

Publications

Modeling human adaptive immune responses with tonsil organoids.

Wagar LE, Salahudeen A, Constantz CM, Wendel BS, Lyons MM, Mallajosyula V, Jatt LP, Adamska JZ, Blum LK, Gupta N, Jackson KJL, Yang F, Röltgen K, Roskin KM, Blaine KM, Meister KD, Ahmad IN, Cortese M, Dora EG, Tucker SN, Sperling AI, Jain A, Davies DH, Felgner PL, Hammer GB, Kim PS, Robinson WH, Boyd SD, Kuo CJ, Davis MM.Nat Med. 2021 Jan;27(1):125-135. doi: 10.1038/s41591-020-01145-0. Epub 2021 Jan 11.

Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.

Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C.Commun Biol. 2019 Nov 13;2:411. doi: 10.1038/s42003-019-0657-2. eCollection 2019.

T cell Co-Stimulatory molecules ICOS and CD28 stratify idiopathic pulmonary fibrosis survival.

Bonham CA, Hrusch CL, Blaine KM, Manns ST, Vij R, Oldham JM, Churpek MM, Strek ME, Noth I, Sperling AI.Respir Med X. 2019;1:100002. doi: 10.1016/j.yrmex.2019.100002. Epub 2019 Feb 1.

Non-apoptotic Fas (CD95) Signaling on T Cells Regulates the Resolution of Th2-Mediated Inflammation.

Williams JW, Ferreira CM, Blaine KM, Rayon C, Velázquez F, Tong J, Peter ME, Sperling AI.Front Immunol. 2018 Nov 1;9:2521. doi: 10.3389/fimmu.2018.02521. eCollection 2018.

Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation.

Ferreira CM, Williams JW, Tong J, Rayon C, Blaine KM, Sperling AI.Front Immunol. 2018 Oct 30;9:2395. doi: 10.3389/fimmu.2018.02395. eCollection 2018.

Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function.

Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI.Front Immunol. 2016 Nov 23;7:516. doi: 10.3389/fimmu.2016.00516. eCollection 2016.

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses.

Tjota MY, Hrusch CL, Blaine KM, Williams JW, Barrett NA, Sperling AI.J Allergy Clin Immunol. 2014 Sep;134(3):706-713.e8. doi: 10.1016/j.jaci.2014.06.013. Epub 2014 Jul 31.

DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry.

Flor AC, Williams JH, Blaine KM, Duggan RC, Sperling AI, Schwartz DA, Kron SJ.Chembiochem. 2014 Jan 24;15(2):267-75. doi: 10.1002/cbic.201300464. Epub 2013 Dec 27.

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI.Nat Commun. 2013;4:2990. doi: 10.1038/ncomms3990.

 

PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod.

Cannon JL, Asperti-Boursin F, Letendre KA, Brown IK, Korzekwa KE, Blaine KM, Oruganti SR, Sperling AI, Moses ME.PLoS One. 2013 Nov 8;8(11):e78940. doi: 10.1371/journal.pone.0078940. eCollection 2013.

Fas Ligand Expression on T Cells Is Sufficient to Prevent Prolonged Airway Inflammation in a Murine Model of Asthma

Jiankun Tong, Bryan S. Clay, Caroline M. Ferreira, Hozefa S. Bandukwala, Tamson V. Moore, Kelly M. Blaine, Jesse W. Williams, Lisa M. Hoffman, Kimm J. Hamann, Rebecca A. Shilling, Joel V. Weinstock, Anne I. Sperling

Am J Respir Cell Mol Biol. 2010 Sep; 43(3): 342–348. Published online 2009 Oct 23. doi: 10.1165/rcmb.2008-0454OC

ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s

Cara L. Hrusch, Stephenie T. Manns, Dana Bryazka, Joshua Casaos, Catherine A. Bonham, Mohammad R. Jaffery, Kelly M. Blaine, Kathleen A.M. Mills, Philip A. Verhoef, Ayodeji O. Adegunsoye, Jesse W. Williams, Melissa Y. Tjota, Tamson V. Moore, Mary E. Strek, Imre Noth, Anne I. Sperling

Mucosal Immunol. Author manuscript; available in PMC 2017 Dec 21.

Published in final edited form as: Mucosal Immunol. 2018 Jan; 11(1): 61–70. Published online 2017 May 10. doi: 10.1038/mi.2017.42

Signaling through CD43 regulates CD4 T-cell trafficking

Purvi D. Mody, Judy L. Cannon, Hozefa S. Bandukwala, Kelly M. Blaine, Alexander B. Schilling, Kevin Swier, Anne I. Sperling

Blood. 2007 Oct 15; 110(8): 2974–2982. Prepublished online 2007 Jul 16. doi: 10.1182/blood-2007-01-065276

Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells

James P. O'Keefe, Kelly Blaine, Maria-Luisa Alegre, Thomas F. Gajewski

Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25): 9351–9356. Published online 2004 Jun 10. doi: 10.1073/pnas.0305965101