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Latest Publications



Engineering Challenges and Opportunities in Autologous Cellular Cancer Immunotherapy.

Foley CR, Swan SL, Swartz MA. J Immunol. 2024 Jan 15;212(2):188-198. doi: 10.4049/jimmunol.2300642. PMID: 38166251.


Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity.

Kang S, Mansurov A, Kurtanich T, Chun HR, Slezak AJ, Volpatti LR, Chang K, Wang T, Alpar AT, Refvik KC, Hansen OI, Borjas GJ, Shim HN, Hultgren KT, Gomes S, Solanki A, Ishihara J, Swartz MA, Hubbell JA. Sci Adv. 2023 Dec;9(48):eadh9879. doi: 10.1126/sciadv.adh9879. Epub 2023 Nov 29. PMID: 38019919; PMCID: PMC10686557.


TGF-β Signaling Prevents MHC Class II-Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4+ T Cells.

Mezyk-Kopec R, Potin L, Gomez Medellin JE, Salles CM, Swartz MA. J Immunol. 2023 Sep 1;211(5):782-790. doi: 10.4049/jimmunol.2200216. PMID: 37486193.

Membrane-localized neoantigens predict the efficacy of cancer immunotherapy.

Goldberger Z, Hauert S, Chang K, Kurtanich T, Alpar AT, Repond G, Wang Y, Gomes S, Krishnakumar R, Siddarth P, Swartz MA, Hubbell JA, Briquez PS. Cell Rep Med. 2023 Aug 15;4(8):101145. doi: 10.1016/j.xcrm.2023.101145. Epub 2023 Aug 7. PMID: 37552990; PMCID: PMC10439248.



Tumor Cell-Surface Binding of Immune Stimulating Polymeric Glyco-Adjuvant via Cysteine-Reactive Pyridyl Disulfide Promotes Antitumor Immunity.

Slezak AJ, Mansurov A, Raczy MM, Chang K, Alpar AT, Lauterbach AL, Wallace RP, Weathered RK, Medellin JEG, Battistella C, Gray LT, Marchell TM, Gomes S, Swartz MA, Hubbell JA.ACS Cent Sci. 2022 Oct 26;8(10):1435-1446. doi: 10.1021/acscentsci.2c00704. Epub 2022 Oct 7.

Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity.

Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA.Sci Adv. 2022 Oct 7;8(40):eabn3777. doi: 10.1126/sciadv.abn3777. Epub 2022 Oct 7.

Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents.

Macdonald ME, Weathered RK, Stewart EC, Magold AI, Mukherje A, Gurbuxani S, Smith H, McMullen P, Mueller J, Husain AN, Mateos Salles C, Briquez PS, Rouhani SJ, Yu J, Trujillo JA, Pyzer AR, Gajewski TF, Sperling AI, Kilarski WW, Swartz MA.Blood Adv. 2022 Aug 17:bloodadvances.2022007798. doi: 10.1182/bloodadvances.2022007798.

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.

Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA.Nat Biomed Eng. 2022 Jul;6(7):819-829. doi: 10.1038/s41551-022-00888-0. Epub 2022 May 9.

Pathogenic Exploitation of Lymphatic Vessels. 

Magold AI, Swartz MA. Cells. 2022 Mar 12;11(6):979. doi: 10.3390/cells11060979.


SARS-CoV-2 infection induces cross-reactive autoantibodies against angiotensin II.

Briquez PS, Rouhani SJ, Yu J, Pyzer AR, Trujillo J, Dugan HL, Stamper CT, Changrob S, Sperling AI, Wilson PC, Gajewski TF, Hubbell JA, Swartz MA.medRxiv. 2021 Nov 2:2021.11.02.21265789. doi: 10.1101/2021.11.02.21265789. Preprint.

Overcoming transport barriers to immunotherapy.

Yu SS, Hubbell JA, Swartz MA.Drug Deliv Transl Res. 2021 Dec;11(6):2273-2275. doi: 10.1007/s13346-021-01084-4. Epub 2021 Oct 30.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant.

Gray LT, Raczy MM, Briquez PS, Marchell TM, Alpar AT, Wallace RP, Volpatti LR, Sasso MS, Cao S, Nguyen M, Mansurov A, Budina E, Watkins EA, Solanki A, Mitrousis N, Reda JW, Yu SS, Tremain AC, Wang R, Nicolaescu V, Furlong K, Dvorkin S, Manicassamy B, Randall G, Wilson DS, Kwissa M, Swartz MA, Hubbell JA.Biomaterials. 2021 Nov;278:121159. doi: 10.1016/j.biomaterials.2021.121159. Epub 2021 Sep 30.

Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance.

Maulloo CD, Cao S, Watkins EA, Raczy MM, Solanki AS, Nguyen M, Reda JW, Shim HN, Wilson DS, Swartz MA, Hubbell JA.Front Immunol. 2021 Sep 24;12:714842. doi: 10.3389/fimmu.2021.714842. eCollection 2021.

MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.

Gkountidi AO, Garnier L, Dubrot J, Angelillo J, Harlé G, Brighouse D, Wrobel LJ, Pick R, Scheiermann C, Swartz MA, Hugues S.Cancer Immunol Res. 2021 Jul;9(7):748-764. doi: 10.1158/2326-6066.CIR-20-0784. Epub 2021 May 5.

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity.

Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA.ACS Cent Sci. 2021 Aug 25;7(8):1368-1380. doi: 10.1021/acscentsci.1c00596. Epub 2021 Jul 21.

Lymphangiogenesis-inducing vaccines elicit potent and long-lasting T cell immunity against melanomas.

Sasso MS, Mitrousis N, Wang Y, Briquez PS, Hauert S, Ishihara J, Hubbell JA, Swartz MA.Sci Adv. 2021 Mar 24;7(13):eabe4362. doi: 10.1126/sciadv.abe4362. Print 2021 Mar.

Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models.

Yuba E, Budina E, Katsumata K, Ishihara A, Mansurov A, Alpar AT, Watkins EA, Hosseinchi P, Reda JW, Lauterbach AL, Nguyen M, Solanki A, Kageyama T, Swartz MA, Ishihara J, Hubbell JA.Arthritis Rheumatol. 2021 May;73(5):769-778. doi: 10.1002/art.41585. Epub 2021 Mar 8.

Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.

Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA.Nat Biomed Eng. 2021 May;5(5):387-398. doi: 10.1038/s41551-020-00627-3. Epub 2020 Oct 12.

Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation.

Maisel K, Hrusch CL, Medellin JEG, Potin L, Chapel DB, Nurmi H, Camacho DF, Gleyzer R, Alitalo K, Sperling AI, Swartz MA.Mucosal Immunol. 2021 Jan;14(1):144-151. doi: 10.1038/s41385-020-0308-4. Epub 2020 Jun 9.


Enhanced lymph node trafficking of engineered IL-10 suppresses rheumatoid arthritis in murine models.

Yuba E, Budina E, Katsumata K, Ishihara A, Mansurov A, Alpar AT, Watkins EA, Hosseinchi P, Reda JW, Lauterbach AL, Nguyen M, Solanki A, Kageyama T, Swartz MA, Ishihara J, Hubbell JA.Arthritis Rheumatol. 2020 Nov 10. doi: 10.1002/art.41585. Online ahead of print.PMID: 33169522

Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.

Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Nat Biomed Eng. 2020 Oct 12. doi: 10.1038/s41551-020-00627-3.

Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation.

Maisel K, Hrusch CL, Medellin JEG, Potin L, Chapel DB, Nurmi H, Camacho DF, Gleyzer R, Alitalo K, Sperling AI, Swartz MA.

Mucosal Immunol. 2020 Jun 9. doi: 10.1038/s41385-020-0308-4. [Epub ahead of print]

Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours.

Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford JM, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA.

Nat Biomed Eng. 2020 Apr 13. doi: 10.1038/s41551-020-0549-2. [Epub ahead of print]

Engineering Targeting Materials for Therapeutic Cancer Vaccines.

Briquez PS, Hauert S, de Titta A, Gray LT, Alpar AT, Swartz MA, Hubbell JA.

Front Bioeng Biotechnol. 2020 Feb 11;8:19. doi: 10.3389/fbioe.2020.00019.

Lymphoidal chemokine CCL19 promoted the heterogeneity of the breast tumor cell motility within a 3D microenvironment revealed by a Lévy distribution analysis.

Kim BJ, Hannanta-Anan P, Ryd A, Swartz MA, Wu M.

Integr Biol (Camb). 2020 Feb 22;12(1):12-20. doi: 10.1093/intbio/zyaa001.

Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions.

Vokali E, Yu SS, Hirosue S, Rinçon-Restrepo M, V Duraes F, Scherer S, Corthésy-Henrioud P, Kilarski WW, Mondino A, Zehn D, Hugues S, Swartz MA.

Nat Commun. 2020 Jan 27;11(1):538. doi: 10.1038/s41467-019-14127-9.

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers.

Card C, Wilson DS, Hirosue S, Rincon-Restrepo M, de Titta A, Güç E, Martin C, Bain O, Swartz MA, Kilarski WW.

Sci Rep. 2020 Jan 23;10(1):1055. doi: 10.1038/s41598-020-57995-8.

Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers.

Galliverti G, Wullschleger S, Tichet M, Murugan D, Zangger N, Horton W, Korman AJ, Coussens LM, Swartz MA, Hanahan D.

Cancer Immunol Res. 2020 Jan;8(1):131-145. doi: 10.1158/2326-6066.CIR-19-0315.


Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy.

Williford JM, Ishihara J, Ishihara A, Mansurov A, Hosseinchi P, Marchell TM, Potin L, Swartz MA, Hubbell JA.

Sci Adv. 2019 Dec 11;5(12):eaay1357. doi: 10.1126/sciadv.aay1357.

Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing.

Mochizuki M, Güç E, Park AJ, Julier Z, Briquez PS, Kuhn GA, Müller R, Swartz MA, Hubbell JA, Martino MM.

Nat Biomed Eng. 2019 Nov 4. doi: 10.1038/s41551-019-0469-1.

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels.

Kilarski WW, Martin C, Pisano M, Bain O, Babayan SA, Swartz MA.

Nat Commun. 2019 Jul 1;10(1):2895. doi: 10.1038/s41467-019-10675-2.

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients.

Broggi MAS, Maillat L, Clement CC, Bordry N, Corthésy P, Auger A, Matter M, Hamelin R, Potin L, Demurtas D, Romano E, Harari A, Speiser DE, Santambrogio L, Swartz MA.

J Exp Med. 2019 May 6;216(5):1091-1107. doi: 10.1084/jem.20181618.

Targeted antibody and cytokine cancer immunotherapies through collagen affinity.

Ishihara J, Ishihara A, Sasaki K, Lee SS, Williford JM, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA.

Sci Transl Med. 2019 Apr 10;11(487). pii: eaau3259. doi: 10.1126/scitranslmed.aau3259.

Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control.

Botelho NK, Tschumi BO, Hubbell JA, Swartz MA, Donda A, Romero P.

Front Immunol. 2019 Feb 26;10:294. doi: 10.3389/fimmu.2019.00294. eCollection 2019.

Trojan horses for immunotherapy.

Hubbell JA, Swartz MA.

Nat Nanotechnol. 2019 Mar;14(3):196-197. doi: 10.1038/s41565-019-0380-7. No abstract available.

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity.

Wilson DS, Hirosue S, Raczy MM, Bonilla-Ramirez L, Jeanbart L, Wang R, Kwissa M, Franetich JF, Broggi MAS, Diaceri G, Quaglia-Thermes X, Mazier D, Swartz MA, Hubbell JA.

Nat Mater. 2019 Feb;18(2):175-185. doi: 10.1038/s41563-018-0256-5.

Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, Randolph GJ.

Cell Metab. 2019 Feb 5;29(2):475-487.e7. doi: 10.1016/j.cmet.2018.10.006.

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model.

Triacca V, Pisano M, Lessert C, Petit B, Bouzourene K, Nahimana A, Vozenin MC, Stergiopulos N, Swartz MA, Mazzolai L.

Eur J Vasc Endovasc Surg. 2019 Jun;57(6):859-867. doi: 10.1016/j.ejvs.2018.04.014.


Dorsal Ear Skin Window for Intravital Imaging and Functional Analysis of Lymphangiogenesis.

Kilarski WW, Güç E, Swartz MA.

Methods Mol Biol. 2018;1846:261-277. doi: 10.1007/978-1-4939-8712-2_17.

Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma.

Bordry N, Broggi MAS, de Jonge K, Schaeuble K, Gannon PO, Foukas PG, Danenberg E, Romano E, Baumgaertner P, Fankhauser M, Wald N, Cagnon L, Abed-Maillard S, Maby-El Hajjami H, Murray T, Ioannidou K, Letovanec I, Yan P, Michielin O, Matter M, Swartz MA, Speiser DE.

Oncoimmunology. 2018 May 31;7(8):e1462878. doi: 10.1080/2162402X.2018.1462878.

Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice.

Galliverti G, Tichet M, Domingos-Pereira S, Hauert S, Nardelli-Haefliger D, Swartz MA, Hanahan D, Wullschleger S.

Cancer Immunol Res. 2018 Nov;6(11):1301-1313. doi: 10.1158/2326-6066.CIR-18-0166.

Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity.

Ishihara J, Ishihara A, Potin L, Hosseinchi P, Fukunaga K, Damo M, Gajewski TF, Swartz MA, Hubbell JA.

Mol Cancer Ther. 2018 Nov;17(11):2399-2411. doi: 10.1158/1535-7163.MCT-18-0091.

Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis.

Maisel K, Merrilees MJ, Atochina-Vasserman EN, Lian L, Obraztsova K, Rue R, Vasserman AN, Zuo N, Angel LF, Gow AJ, Kang I, Wight TN, Eruslanov E, Swartz MA, Krymskaya VP.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):723-732. doi: 10.1165/rcmb.2018-0123OC.


Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events.

Ishihara J, Fukunaga K, Ishihara A, Larsson HM, Potin L, Hosseinchi P, Galliverti G, Swartz MA, Hubbell JA.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaan0401. doi: 10.1126/scitranslmed.aan0401.


Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein.


Galan-Navarro C, Rincon-Restrepo M, Zimmer G, Ollmann Saphire E, Hubbell JA, Hirosue S, Swartz MA, Kunz S.

Virology. 2017 Dec;512:161-171. doi: 10.1016/j.virol.2017.09.013.

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.

Fankhauser M, Broggi MAS, Potin L, Bordry N, Jeanbart L, Lund AW, Da Costa E, Hauert S, Rincon-Restrepo M, Tremblay C, Cabello E, Homicsko K, Michielin O, Hanahan D, Speiser DE, Swartz MA.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaal4712. doi: 10.1126/scitranslmed.aal4712.

Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges.

Maisel K, Sasso MS, Potin L, Swartz MA.

Adv Drug Deliv Rev. 2017 May 15;114:43-59. doi: 10.1016/j.addr.2017.07.005.

Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling.

Güç E, Briquez PS, Foretay D, Fankhauser MA, Hubbell JA, Kilarski WW, Swartz MA.

Biomaterials. 2017 Jul;131:160-175. doi: 10.1016/j.biomaterials.2017.03.033.

Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses.

Rincon-Restrepo M, Mayer A, Hauert S, Bonner DK, Phelps EA, Hubbell JA, Swartz MA, Hirosue S.

Biomaterials. 2017 Jul;132:48-58. doi: 10.1016/j.biomaterials.2017.03.047.

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.

Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninković J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O.

J Allergy Clin Immunol. 2017 Nov;140(5):1339-1350. doi: 10.1016/j.jaci.2016.12.985.

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress.

Triacca V, Güç E, Kilarski WW, Pisano M, Swartz MA.

Circ Res. 2017 Apr 28;120(9):1440-1452. doi: 10.1161/CIRCRESAHA.116.309828.

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.

Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S.

Diabetes. 2017 Feb;66(2):460-473. doi: 10.2337/db16-0671.

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors.

Manzo T, Sturmheit T, Basso V, Petrozziello E, Hess Michelini R, Riba M, Freschi M, Elia AR, Grioni M, Curnis F, Protti MP, Schumacher TN, Debets R, Swartz MA, Corti A, Bellone M, Mondino A.

Cancer Res. 2017 Feb 1;77(3):658-671. doi: 10.1158/0008-5472.CAN-16-0725.


Connecting (T)issues: How Research in Fascia Biology Can Impact Integrative Oncology.

Langevin HM, Keely P, Mao J, Hodge LM, Schleip R, Deng G, Hinz B, Swartz MA, de Valois BA, Zick S, Findley T.

Cancer Res. 2016 Nov 1;76(21):6159-6162.

Perivascular Macrophages Limit Permeability.

He H, Mack JJ, Güç E, Warren CM, Squadrito ML, Kilarski WW, Baer C, Freshman RD, McDonald AI, Ziyad S, Swartz MA, De Palma M, Iruela-Arispe ML.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2203-2212.

Lymphatic vessels regulate immune microenvironments in human and murine melanoma.

Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA.

J Clin Invest. 2016 Sep 1;126(9):3389-402. doi: 10.1172/JCI79434. 


Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses.

Julier Z, de Titta A, Grimm AJ, Simeoni E, Swartz MA, Hubbell JA.

Vaccine. 2016 May 5;34(21):2453-2459. doi: 10.1016/j.vaccine.2016.03.057.

Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1.

Caucheteux SM, Mitchell JP, Ivory MO, Hirosue S, Hakobyan S, Dolton G, Ladell K, Miners K, Price DA, Kan-Mitchell J, Sewell AK, Nestle F, Moris A, Karoo RO, Birchall JC, Swartz MA, Hubbel JA, Blanchet FP, Piguet V.

J Invest Dermatol. 2016 Jun;136(6):1172-1181. doi: 10.1016/j.jid.2016.01.033.


Engineering opportunities in cancer immunotherapy.

Jeanbart L, Swartz MA.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14467-72. doi: 10.1073/pnas.1508516112.

Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3242.

Tissue mechanics: Cell jam.

Swartz MA.

Nat Mater. 2015 Oct;14(10):970-1. doi: 10.1038/nmat4434.

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice.

Ballester M, Jeanbart L, de Titta A, Nembrini C, Marsland BJ, Hubbell JA, Swartz MA.

Sci Rep. 2015 Sep 21;5:14274.

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.

Procopio MG, Laszlo C, Al Labban D, Kim DE, Bordignon P, Jo SH, Goruppi S, Menietti E, Ostano P, Ala U, Provero P, Hoetzenecker W, Neel V, Kilarski WW, Swartz MA, Brisken C, Lefort K, Dotto GP.

Nat Cell Biol. 2015 Sep;17(9):1193-204. doi: 10.1038/ncb3228.

ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.

Mężyk-Kopeć R, Wyroba B, Stalińska K, Próchnicki T, Wiatrowska K, Kilarski WW, Swartz MA, Bereta J.

PLoS One. 2015 Jul 15;10(7):e0132661. doi: 10.1371/journal.pone.0132661.

6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice.

Jeanbart L, Kourtis IC, van der Vlies AJ, Swartz MA, Hubbell JA.

Cancer Immunol Immunother. 2015 Aug;64(8):1033-46. doi: 10.1007/s00262-015-1702-8.

Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node-homing adipose tissue dendritic cells.

Kuan EL, Ivanov S, Bridenbaugh EA, Victora G, Wang W, Childs EW, Platt AM, Jakubzick CV, Mason RJ, Gashev AA, Nussenzweig M, Swartz MA, Dustin ML, Zawieja DC, Randolph GJ.

J Immunol. 2015 Jun 1;194(11):5200-10. doi: 10.4049/jimmunol.1500221.

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion.

Pisano M, Triacca V, Barbee KA, Swartz MA.

Integr Biol (Camb). 2015 May;7(5):525-33. doi: 10.1039/c5ib00085h.


Inflammatory lymphangiogenesis in postpartum breast tissue remodeling.

Swartz MA.

J Clin Invest. 2014 Sep;124(9):3704-7. doi: 10.1172/JCI77765.

Immunomodulatory roles of lymphatic vessels in cancer progression.

Swartz MA.

Cancer Immunol Res. 2014 Aug;2(8):701-7. doi: 10.1158/2326-6066.CIR-14-0115.

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.

Dubrot J, Duraes FV, Potin L, Capotosti F, Brighouse D, Suter T, LeibundGut-Landmann S, Garbi N, Reith W, Swartz MA, Hugues S.

J Exp Med. 2014 Jun 2;211(6):1153-66. doi: 10.1084/jem.20132000.

Long-term intravital immunofluorescence imaging of tissue matrix components with epifluorescence and two-photon microscopy.

Güç E, Fankhauser M, Lund AW, Swartz MA, Kilarski WW.

J Vis Exp. 2014 Apr 22;(86). doi: 10.3791/51388.


Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells.


Hirosue S, Vokali E, Raghavan VR, Rincon-Restrepo M, Lund AW, Corthésy-Henrioud P, Capotosti F, Halin Winter C, Hugues S, Swartz MA. J Immunol. 2014 Jun 1;192(11):5002-11. doi: 10.4049/jimmunol.1302492.

Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes.

Jeanbart L, Ballester M, de Titta A, Corthésy P, Romero P, Hubbell JA, Swartz MA.

Cancer Immunol Res. 2014 May;2(5):436-47. doi: 10.1158/2326-6066.CIR-14-0019-T.

Introduction to the special issue on lymphangiogenesis in inflammation.

Swartz MA, Randolph GJ.

Angiogenesis. 2014 Apr;17(2):323-4. doi: 10.1007/s10456-014-9427-4.

Emerging roles of lymphatic endothelium in regulating adaptive immunity.

Card CM, Yu SS, Swartz MA.

J Clin Invest. 2014 Mar;124(3):943-52. doi: 10.1172/JCI73316.

Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing.

Martino MM, Briquez PS, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ, Kuhn GA, Müller R, Swartz MA, Hubbell JA.

Science. 2014 Feb 21;343(6173):885-8. doi: 10.1126/science.1247663.


Modeling tumor microenvironments in vitro.

Wu M, Swartz MA.

J Biomech Eng. 2014 Feb;136(2):021011. doi: 10.1115/1.4026447.


Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.

de Titta A, Ballester M, Julier Z, Nembrini C, Jeanbart L, van der Vlies AJ, Swartz MA, Hubbell JA.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19902-7. doi: 10.1073/pnas.1313152110.

Engineering synthetic vaccines using cues from natural immunity.

Irvine DJ, Swartz MA, Szeto GL.

Nat Mater. 2013 Nov;12(11):978-90. doi: 10.1038/nmat3775.

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response.

Thomas SN, Vokali E, Lund AW, Hubbell JA, Swartz MA.

Biomaterials. 2014 Jan;35(2):814-24. doi: 10.1016/j.biomaterials.2013.10.003.

VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy.

Rutkowski JM, Ihm JE, Lee ST, Kilarski WW, Greenwood VI, Pasquier MC, Quazzola A, Trono D, Hubbell JA, Swartz MA.

Am J Pathol. 2013 Nov;183(5):1596-1607. doi: 10.1016/j.ajpath.2013.07.031.

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis.

Kilarski WW, Muchowicz A, Wachowska M, Mężyk-Kopeć R, Golab J, Swartz MA, Nowak-Sliwinska P.

Angiogenesis. 2014 Apr;17(2):347-57. doi: 10.1007/s10456-013-9365-6.

Cooperative roles of SDF-1α and EGF gradients on tumor cell migration revealed by a robust 3D microfluidic model.

Kim BJ, Hannanta-anan P, Chau M, Kim YS, Swartz MA, Wu M.

PLoS One. 2013 Jul 15;8(7):e68422. doi: 10.1371/journal.pone.0068422.

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165.

Traub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA.

Biomaterials. 2013 Aug;34(24):5958-68. doi: 10.1016/j.biomaterials.2013.04.050.

Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice.

Kourtis IC, Hirosue S, de Titta A, Kontos S, Stegmann T, Hubbell JA, Swartz MA.

PLoS One. 2013 Apr 23;8(4):e61646. doi: 10.1371/journal.pone.0061646.

Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia.

Platt AM, Rutkowski JM, Martel C, Kuan EL, Ivanov S, Swartz MA, Randolph GJ.

J Immunol. 2013 May 1;190(9):4608-20. doi: 10.4049/jimmunol.1202600.

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice.

Martel C, Li W, Fulp B, Platt AM, Gautier EL, Westerterp M, Bittman R, Tall AR, Chen SH, Thomas MJ, Kreisel D, Swartz MA, Sorci-Thomas MG, Randolph GJ.

J Clin Invest. 2013 Apr;123(4):1571-9. doi: 10.1172/JCI63685.

Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles.

Stano A, Scott EA, Dane KY, Swartz MA, Hubbell JA.

Biomaterials. 2013 Jun;34(17):4339-46. doi: 10.1016/j.biomaterials.2013.02.024.

Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis.

Kilarski WW, Güç E, Teo JC, Oliver SR, Lund AW, Swartz MA.

PLoS One. 2013;8(2):e57135. doi: 10.1371/journal.pone.0057135.

Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism.

Munson JM, Bellamkonda RV, Swartz MA.

Cancer Res. 2013 Mar 1;73(5):1536-46. doi: 10.1158/0008-5472.CAN-12-2838.


ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis.

Das S, Czarnek M, Bzowska M, Mężyk-Kopeć R, Stalińska K, Wyroba B, Sroka J, Jucha J, Deneka D, Stokłosa P, Ogonek J, Swartz MA, Madeja Z, Bereta J.

PLoS One. 2012;7(12):e50791. doi: 10.1371/journal.pone.0050791.

Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization.

Stano A, Nembrini C, Swartz MA, Hubbell JA, Simeoni E.

Vaccine. 2012 Dec 14;30(52):7541-6. doi: 10.1016/j.vaccine.2012.10.050.

Engineering approaches to immunotherapy.

Swartz MA, Hirosue S, Hubbell JA.

Sci Transl Med. 2012 Aug 22;4(148):148rv9. doi: 10.1126/scitranslmed.3003763.

Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.

Thomas SN, Rutkowski JM, Pasquier M, Kuan EL, Alitalo K, Randolph GJ, Swartz MA.

J Immunol. 2012 Sep 1;189(5):2181-90. doi: 10.4049/jimmunol.1103545.

VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics.

Lund AW, Duraes FV, Hirosue S, Raghavan VR, Nembrini C, Thomas SN, Issa A, Hugues S, Swartz MA.

Cell Rep. 2012 Mar 29;1(3):191-9. doi: 10.1016/j.celrep.2012.01.005.

Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer.

Wiig H, Swartz MA.

Physiol Rev. 2012 Jul;92(3):1005-60. doi: 10.1152/physrev.00037.2011.

Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization.

Eby JK, Dane KY, O'Neil CP, Hirosue S, Swartz MA, Hubbell JA.

Acta Biomater. 2012 Sep;8(9):3210-7. doi: 10.1016/j.actbio.2012.06.007.

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes.

Scott EA, Stano A, Gillard M, Maio-Liu AC, Swartz MA, Hubbell JA.

Biomaterials. 2012 Sep;33(26):6211-9. doi: 10.1016/j.biomaterials.2012.04.060.

Tumor microenvironment complexity: emerging roles in cancer therapy.

Swartz MA, Iida N, Roberts EW, Sangaletti S, Wong MH, Yull FE, Coussens LM, DeClerck YA.

Cancer Res. 2012 May 15;72(10):2473-80. doi: 10.1158/0008-5472.CAN-12-0122.

Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity.

Swartz MA, Lund AW.

Nat Rev Cancer. 2012 Feb 24;12(3):210-9. doi: 10.1038/nrc3186. R


Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber.

Haessler U, Teo JC, Foretay D, Renaud P, Swartz MA.

Integr Biol (Camb). 2012 Apr;4(4):401-9. doi: 10.1039/c1ib00128k.



Multiscale modeling of lymphatic drainage from tissues using homogenization theory.

Roose T, Swartz MA.

J Biomech. 2012 Jan 3;45(1):107-15. doi: 10.1016/j.jbiomech.2011.09.015.


Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination.


Nembrini C, Stano A, Dane KY, Ballester M, van der Vlies AJ, Marsland BJ, Swartz MA, Hubbell JA.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E989-97. doi: 10.1073/pnas.1104264108.

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: tumor immunotoxicity in B16F10 melanoma.

Velluto D, Thomas SN, Simeoni E, Swartz MA, Hubbell JA.

Biomaterials. 2011 Dec;32(36):9839-47. doi: 10.1016/j.biomaterials.2011.08.079.

Improvement of bowel dysfunction with sacral neuromodulation for refractory urge urinary incontinence.

Gill BC, Swartz MA, Rackley RR, Moore CK, Goldman HB, Vasavada SP.

Int Urogynecol J. 2012 Jun;23(6):735-41. doi: 10.1007/s00192-011-1553-6.

Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival.

Dane KY, Nembrini C, Tomei AA, Eby JK, O'Neil CP, Velluto D, Swartz MA, Inverardi L, Hubbell JA.

J Control Release. 2011 Dec 10;156(2):154-60. doi: 10.1016/j.jconrel.2011.08.009.

Improved sexual and urinary function in women with sacral nerve stimulation.

Gill BC, Swartz MA, Firoozi F, Rackley RR, Moore CK, Goldman HB, Vasavada SP.

Neuromodulation. 2011 Sep-Oct;14(5):436-43; discussion 443. doi: 10.1111/j.1525-1403.2011.00380.x.

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis.

Ballester M, Nembrini C, Dhar N, de Titta A, de Piano C, Pasquier M, Simeoni E, van der Vlies AJ, McKinney JD, Hubbell JA, Swartz MA.

Vaccine. 2011 Sep 16;29(40):6959-66. doi: 10.1016/j.vaccine.2011.07.039.

Pulmonary emboli detected by endobronchial ultrasound.

Swartz MA, Gillespie CT.

Am J Respir Crit Care Med. 2011 Jun 1;183(11):1569. doi: 10.1164/rccm.201009-1477IM.

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19.

Haessler U, Pisano M, Wu M, Swartz MA.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5614-9. doi: 10.1073/pnas.1014920108.

Regulation of tumor invasion by interstitial fluid flow.

Shieh AC, Swartz MA.

Phys Biol. 2011 Feb;8(1):015012. doi: 10.1088/1478-3975/8/1/015012.

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts.

Shieh AC, Rozansky HA, Hinz B, Swartz MA.

Cancer Res. 2011 Feb 1;71(3):790-800. doi: 10.1158/0008-5472.CAN-10-1513.

Engineering complement activation on polypropylene sulfide vaccine nanoparticles.

Thomas SN, van der Vlies AJ, O'Neil CP, Reddy ST, Yu SS, Giorgio TD, Swartz MA, Hubbell JA.

Biomaterials. 2011 Mar;32(8):2194-203. doi: 10.1016/j.biomaterials.2010.11.037.

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration.

Stano A, van der Vlies AJ, Martino MM, Swartz MA, Hubbell JA, Simeoni E.

Vaccine. 2011 Jan 17;29(4):804-12. doi: 10.1016/j.vaccine.2010.11.010.


Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation.

Hirosue S, Kourtis IC, van der Vlies AJ, Hubbell JA, Swartz MA.

Vaccine. 2010 Nov 23;28(50):7897-906. doi: 10.1016/j.vaccine.2010.09.077.

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Lund AW, Swartz MA.

J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):341-52. doi: 10.1007/s10911-010-9193-x.

Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21.

Shields JD, Kourtis IC, Tomei AA, Roberts JM, Swartz MA.

Science. 2010 May 7;328(5979):749-52. doi: 10.1126/science.1185837.

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium.

Miteva DO, Rutkowski JM, Dixon JB, Kilarski W, Shields JD, Swartz MA.

Circ Res. 2010 Mar 19;106(5):920-31. doi: 10.1161/CIRCRESAHA.109.207274.

Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.

Rutkowski JM, Markhus CE, Gyenge CC, Alitalo K, Wiig H, Swartz MA.

Am J Pathol. 2010 Mar;176(3):1122-9. doi: 10.2353/ajpath.2010.090733.

Cells in 3D matrices under interstitial flow: effects of extracellular matrix alignment on cell shear stress and drag forces.

Pedersen JA, Lichter S, Swartz MA.

J Biomech. 2010 Mar 22;43(5):900-5. doi: 10.1016/j.jbiomech.2009.11.007.


A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: development, characterization, and applications.

Bonvin C, Overney J, Shieh AC, Dixon JB, Swartz MA.

Biotechnol Bioeng. 2010 Apr 1;105(5):982-91. doi: 10.1002/bit.22608.


Materials engineering for immunomodulation.

Hubbell JA, Thomas SN, Swartz MA.

Nature. 2009 Nov 26;462(7272):449-60. doi: 10.1038/nature08604. Review.


Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment.

Tomei AA, Siegert S, Britschgi MR, Luther SA, Swartz MA.

J Immunol. 2009 Oct 1;183(7):4273-83. doi: 10.4049/jimmunol.0900835.

Single-port laparoscopic abdominal sacral colpopexy: initial experience and comparative outcomes.

White WM, Goel RK, Swartz MA, Moore C, Rackley RR, Kaouk JH.

Urology. 2009 Nov;74(5):1008-12. doi: 10.1016/j.urology.2009.02.086.

Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration.

Lim HY, Rutkowski JM, Helft J, Reddy ST, Swartz MA, Randolph GJ, Angeli V.

Am J Pathol. 2009 Sep;175(3):1328-37. doi: 10.2353/ajpath.2009.080963.

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics.

Dixon JB, Raghunathan S, Swartz MA.

Biotechnol Bioeng. 2009 Aug 15;103(6):1224-35. doi: 10.1002/bit.22337.

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies.

Haessler U, Kalinin Y, Swartz MA, Wu M.

Biomed Microdevices. 2009 Aug;11(4):827-35. doi: 10.1007/s10544-009-9299-3.

In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.

BéruBé K, Aufderheide M, Breheny D, Clothier R, Combes R, Duffin R, Forbes B, Gaça M, Gray A, Hall I, Kelly M, Lethem M, Liebsch M, Merolla L, Morin JP, Seagrave J, Swartz MA, Tetley TD, Umachandran M.

Altern Lab Anim. 2009 Feb;37(1):89-141. No abstract available.

3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support.

Tomei AA, Boschetti F, Gervaso F, Swartz MA.

Biotechnol Bioeng. 2009 May 1;103(1):217-25. doi: 10.1002/bit.22236.

Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype.

Issa A, Le TX, Shoushtari AN, Shields JD, Swartz MA.

Cancer Res. 2009 Jan 1;69(1):349-57. doi: 10.1158/0008-5472.CAN-08-1875.


Design, fabrication, and characterization of a composite scaffold for bone tissue engineering.

Boschetti F, Tomei AA, Turri S, Swartz MA, Levi M.

Int J Artif Organs. 2008 Aug;31(8):697-707.

Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design.

Swartz MA, Hubbell JA, Reddy ST.

Semin Immunol. 2008 Apr;20(2):147-56. doi: 10.1016/j.smim.2007.11.007.

Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model.

Tomei AA, Choe MM, Swartz MA.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L79-86.


Exploiting lymphatic transport and complement activation in nanoparticle vaccines.

Reddy ST, van der Vlies AJ, Simeoni E, Angeli V, Randolph GJ, O'Neil CP, Lee LK, Swartz MA, Hubbell JA.

Nat Biotechnol. 2007 Oct;25(10):1159-64.

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.

Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA.

Cancer Cell. 2007 Jun;11(6):526-38.

An ultra-thin PDMS membrane as a bio/micro-nano interface: fabrication and characterization.

Thangawng AL, Ruoff RS, Swartz MA, Glucksberg MR.

Biomed Microdevices. 2007 Aug;9(4):587-95.

Admission for nephrolithiasis in pregnancy and risk of adverse birth outcomes.

Swartz MA, Lydon-Rochelle MT, Simon D, Wright JL, Porter MP.

Obstet Gynecol. 2007 May;109(5):1099-104.

Interstitial flow and its effects in soft tissues.

Swartz MA, Fleury ME.

Annu Rev Biomed Eng. 2007;9:229-56.

Complications of scrotal surgery for benign conditions.

Swartz MA, Morgan TM, Krieger JN.

Urology. 2007 Apr;69(4):616-9.

Bond-detach lithography: a method for micro/nanolithography by precision PDMS patterning.

Thangawng AL, Swartz MA, Glucksberg MR, Ruoff RS.

Small. 2007 Jan;3(1):132-8.

Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis.

Goldman J, Rutkowski JM, Shields JD, Pasquier MC, Cui Y, Schmökel HG, Willey S, Hicklin DJ, Pytowski B, Swartz MA.

FASEB J. 2007 Apr;21(4):1003-12. Epub 2007 Jan 8. Erratum in: FASEB J. 2007 Jun;21(8):1942.


Physiological 3D tissue model of the airway wall and mucosa.

Choe MM, Tomei AA, Swartz MA.

Nat Protoc. 2006;1(1):357-62.

Regulation of lymphatic capillary regeneration by interstitial flow in skin.

Goldman J, Conley KA, Raehl A, Bondy DM, Pytowski B, Swartz MA, Rutkowski JM, Jaroch DB, Ongstad EL.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2176-83. Epub 2006 Dec 22.

Incidence of primary urethral carcinoma in the United States.

Swartz MA, Porter MP, Lin DW, Weiss NS.

Urology. 2006 Dec;68(6):1164-8.

A driving force for change: interstitial flow as a morphoregulator.

Rutkowski JM, Swartz MA.

Trends Cell Biol. 2007 Jan;17(1):44-50.

Engineered blood and lymphatic capillaries in 3-D VEGF-fibrin-collagen matrices with interstitial flow.

Helm CL, Zisch A, Swartz MA.

Biotechnol Bioeng. 2007 Jan 1;96(1):167-76.

Targeting dendritic cells with biomaterials: developing the next generation of vaccines.

Reddy ST, Swartz MA, Hubbell JA.

Trends Immunol. 2006 Dec;27(12):573-9. Epub 2006 Oct 16.

Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix.

Pedersen JA, Boschetti F, Swartz MA.

J Biomech. 2007;40(7):1484-92.

Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9.

Rutkowski JM, Moya M, Johannes J, Goldman J, Swartz MA.

Microvasc Res. 2006 Nov;72(3):161-71.

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.

Reddy ST, Berk DA, Jain RK, Swartz MA.

J Appl Physiol (1985). 2006 Oct;101(4):1162-9.

Characterization of lymphangiogenesis in a model of adult skin regeneration.

Rutkowski JM, Boardman KC, Swartz MA.

Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1402-10.

Autologous morphogen gradients by subtle interstitial flow and matrix interactions.

Fleury ME, Boardman KC, Swartz MA.

Biophys J. 2006 Jul 1;91(1):113-21.

Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model.

Choe MM, Sporn PH, Swartz MA.

Am J Respir Cell Mol Biol. 2006 Sep;35(3):306-13.

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles.

Reddy ST, Rehor A, Schmoekel HG, Hubbell JA, Swartz MA.

J Control Release. 2006 May 1;112(1):26-34.

Capturing complex 3D tissue physiology in vitro.

Griffith LG, Swartz MA.

Nat Rev Mol Cell Biol. 2006 Mar;7(3):211-24.

Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures.

Ng CP, Swartz MA.

Ann Biomed Eng. 2006 Mar;34(3):446-54.


Microarray analysis of VEGF-C responsive genes in human lymphatic endothelial cells.

Yong C, Bridenbaugh EA, Zawieja DC, Swartz MA.

Lymphat Res Biol. 2005;3(4):183-207.

Mechanobiology in the third dimension.

Pedersen JA, Swartz MA.

Ann Biomed Eng. 2005 Nov;33(11):1469-90.

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism.

Helm CL, Fleury ME, Zisch AH, Boschetti F, Swartz MA.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15779-84.

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro.

Ng CP, Hinz B, Swartz MA.

J Cell Sci. 2005 Oct 15;118(Pt 20):4731-9.

Dendritic-cell trafficking to lymph nodes through lymphatic vessels.

Randolph GJ, Angeli V, Swartz MA.

Nat Rev Immunol. 2005 Aug;5(8):617-28. Review.

Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin.

Goldman J, Le TX, Skobe M, Swartz MA.

Circ Res. 2005 Jun 10;96(11):1193-9.

Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody.

Pytowski B, Goldman J, Persaud K, Wu Y, Witte L, Hicklin DJ, Skobe M, Boardman KC, Swartz MA.

J Natl Cancer Inst. 2005 Jan 5;97(1):14-21.


Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro.

Ng CP, Helm CL, Swartz MA.

Microvasc Res. 2004 Nov;68(3):258-64.


Signaling in morphogenesis: transport cues in morphogenesis.

Swartz MA.

Curr Opin Biotechnol. 2003 Oct;14(5):547-50.

An in vitro airway wall model of remodeling.

Choe MM, Sporn PH, Swartz MA.

Am J Physiol Lung Cell Mol Physiol. 2003

Interstitial flow as a guide for lymphangiogenesis.

Boardman KC, Swartz MA.

Circ Res. 2003 Apr 18;92(7):801-8.


The role of interstitial stress in lymphatic function and lymphangiogenesis.

Swartz MA, Boardman KC Jr.

Ann N Y Acad Sci. 2002 Dec;979:197-210; discussion 229-34.

Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model.

Ng CP, Swartz MA.

Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1771-7. Epub 2003 Jan 16. Erratum in: Am J Physiol Heart Circ Physiol. 2005 Jun;288(6):H3016.

Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications.

Swartz MA, Karth J, Schneider DT, Rodriguez R, Beckwith JB, Perlman EJ.

Urology. 2002 Dec;60(6):1083-9.


Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.

Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, Drazen JM.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L904-11.


Lymphatic function, lymphangiogenesis, and cancer metastasis.

Swartz MA, Skobe M.

Microsc Res Tech. 2001 Oct 15;55(2):92-9. Review.

The physiology of the lymphatic system.

Swartz MA.

Adv Drug Deliv Rev. 2001 Aug 23;50(1-2):3-20. Review.

Mechanical stress is communicated between different cell types to elicit matrix remodeling.

Swartz MA, Tschumperlin DJ, Kamm RD, Drazen JM.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6180-5.

A potential murine model for flap-related investigations.

Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA.

Plast Reconstr Surg. 2001 May;107(6):1504-8.


Role of extracellular matrix assembly in interstitial transport in solid tumors.

Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK.

Cancer Res. 2000 May 1;60(9):2497-503.


Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.

Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK.

J Biomech. 1999 Dec;32(12):1297-307.

Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.

Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK.

Br J Cancer. 1999 Nov;81(5):756-9.

Return of lymphatic function after flap transfer for acute lymphedema.

Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK.

Ann Surg. 1999 Mar;229(3):421-7.


Influence of intravenous perfluorocarbon administration on the dynamic behavior of lung surfactant.

Eckmann DM, Swartz MA, Gavriely N, Glucksberg MR, Grotberg JB.

Artif Cells Blood Substit Immobil Biotechnol. 1998 Jul;26(4):359-66.

Perfluorocarbon induced alterations in pulmonary mechanics.

Eckmann DM, Swartz MA, Glucksberg MR, Gavriely N, Grotberg JB.

Artif Cells Blood Substit Immobil Biotechnol. 1998 May;26(3):259-71.


Development of a patient-focused, interdisciplinary antimicrobial management program involving staff pharmacists.

Lacy MK, Swartz MA, Eidem LA, Bond JA.

Am J Health Syst Pharm. 1997 Aug 15;54(16):1837-41.

Respiratory failure following stereotactic neurosurgery in a 53-year-old woman.

Swartz MA, Munz M, Stern MB.

Chest. 1997 Apr;111(4):1112-4.


Unilateral adrenal enlargement due to Histoplasma capsulatum.

Swartz MA, Scofield RH, Dickey WD, Kirk JL Jr, Wilson DA, Pitha JV, Muchmore HG.

Clin Infect Dis. 1996 Oct;23(4):813-5.

Methods of documenting cost savings associated with an antibiotic management program.

Lacy MK, Eidem LA, Bond JA, Swartz MA.

Pharm Pract Manag Q. 1996 Jul;16(2):66-70.

Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.

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Am J Physiol. 1996 Jan;270(1 Pt 2):H324-9.

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