Alexandra I. Magold, PhD
Alexandra received her BS/MS degree in Molecular Medicine from the University of Freiburg in Germany. In 2011, she completed her PhD in Neuroscience at the Swiss Federal Institute of Technology, working on Alzheimer's Disease (AD). Her PhD research revealed the broad involvement of Wnt pathways in gamma secretase dependent gene expression in mouse models and human brain tissue. Investigating the role of cerebral ciliation Alex collaborated with the Swartz-lab, where she continued her postdoc discovering lymphatic endothelial ciliation. After a stint at the Weizmann Institute working on Cancer Stem Cell Biology and p53 dependent mechanisms, she has rejoined our group which had in the meanwhile relocated to the University of Chicago.
Lymphatic Endothelial Ciliation
Cilia are smart data processing units, turning mechanosensation into cell signaling.
I have reason to believe that the cilia I discovered on lymphatic endothelial cells play roles in the immune activation of the lymphatic endothelium.
Currently I am using the mouse model we developed, investigating phenotypes of reduced lymphatic endothelial ciliation (more concrete info to follow after publication).
I have also developed a deep interest in lymphatic endothelial roles in various infectious diseases and am part of our COVID team.
PME Immunoengineering Science Hour - Microscopy special 2021 program
Lymphatic endothelial ciliation
Primary cilia on lymphatic endothelial cells and their roles in flow sensing
Magold AI, Swartz MA.Cells. 2022 Mar 12;11(6):979. doi: 10.3390/cells11060979.
MacDonald ME, Weathered RK, Stewart EC, Magold AI, Mukherjee A, Gurbuxani S, Smith H, McMullen P, Mueller J, Husain AN, Mateos Salles C, Briquez PS, Rouhani SJ, Yu J, Trujillo JA, Pyzer AR, Gajewski TF, Sperling AI, Kilarski WW, Swartz MA.Blood Adv. 2022 Aug 17:bloodadvances.2022007798. doi: 10.1182/bloodadvances.2022007798.
Magold AI, Cacquevel M, Fraering PC.PLoS One. 2009 Sep 18;4(9):e6952. doi: 10.1371/journal.pone.0006952.
Schessl J, Goemans NM, Magold AI, Zou Y, Hu Y, Kirschner J, Sciot R, Bönnemann CG.Muscle Nerve. 2008 Sep;38(3):1184-91. doi: 10.1002/mus.21088.