Lucas Shores

PostDoc

Lucas Shores originally hails from Sequim, WA. He completed his Bachelor’s degree in Biomedical Engineering from Johns Hopkins University in 2015 where he conducted research on tissue engineering and regenerative medicine in the lab of Jennifer Elisseeff. He then accepted a position as postbaccalaureate through the NIH Intramural Research Training program where he worked in the lab of Jon Yewdell.  He recently defended his PhD in the lab of Joel Collier at Duke University studying supramolecular nanofiber vaccines before joining the Swartz and Hubbell labs as a co-advisee. His love for research is only matched by his love for his dog, Gogi, coffee, and a perfect dreary day.

Current Research

Lucas’ research interests lie at the intersection of research on lymphatics, diabetes, and immune engineering for regenerative medicine. This interdisciplinary focus leverages techniques from several disciplines to develop novel, translationally-oriented, and disease-targeted therapeutics.

Publications

Modular complement assemblies for mitigating inflammatory conditions.

Hainline KM, Shores LS, Votaw NL, Bernstein ZJ, Kelly SH, Fries CN, Madhira MS, Gilroy CA, Chilkoti A, Collier JH.Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2018627118. doi: 10.1073/pnas.2018627118.

Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Shores LS, Kelly SH, Hainline KM, Suwanpradid J, MacLeod AS, Collier JH.Front Immunol. 2020 Aug 18;11:1855. doi: 10.3389/fimmu.2020.01855. eCollection 2020.

Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.

Si Y, Tian Q, Zhao F, Kelly SH, Shores LS, Camacho DF, Sperling AI, Andrade MS, Collier JH, Chong AS.Sci Adv. 2020 Aug 7;6(32):eaba0995. doi: 10.1126/sciadv.aba0995. eCollection 2020 Aug.

Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants.

Majumdar S, Wang X, Sommerfeld SD, Chae JJ, Athanasopoulou EN, Shores LS, Duan X, Amzel LM, Stellacci F, Schein O, Guo Q, Singh A, Elisseeff JH.Adv Funct Mater. 2018 Oct 10;28(41):1804076. doi: 10.1002/adfm.201804076. Epub 2018 Aug 17.

Biomaterial strategies for generating therapeutic immune responses.

Kelly SH, Shores LS, Votaw NL, Collier JH.Adv Drug Deliv Rev. 2017 May 15;114:3-18. doi: 10.1016/j.addr.2017.04.009. Epub 2017 Apr 25.

Use of a chondroitin sulfate bioadhesive to enhance integration of bioglass particles for repairing critical-size bone defects.

Yang S, Guo Q, Shores LS, Aly A, Ramakrishnan M, Kim GH, Lu Q, Su L, Elisseeff JH.J Biomed Mater Res A. 2015 Jan;103(1):235-42. doi: 10.1002/jbm.a.35143. Epub 2014 Apr 2.